BIO-RAD
PAPER DESCRIBES THE EFFECT OF RNA DEGRADATION ON DATA QUALITY IN QUANTITATIVE
PCR AND MICROARRAY EXPERIMENTS
HERCULES, CA – January 30, 2008 – Bio-Rad Laboratories, Inc. (AMEX: BIO
and BIOb), a multinational manufacturer and distributor of life science
research and clinical diagnostic products, today announced the availability of
a technical paper (bulletin 5452A) that describes the effect of RNA degradation
on data quality in quantitative PCR and microarray experiments. The paper
describes using automated electrophoresis to determine RNA quality prior to
gene expression analysis.
Quantitative expression levels,
when determined by qPCR, decrease as RNA becomes
increasingly degraded. This can lead to erroneous conclusions regarding the
levels of gene expression when comparing samples that are degraded to different
extents. Genes with high levels of expression can still be characterized but
degradation compromises the ability to detect differences in genes that are
expressed at low levels.
Bio-Rad’s Experion™ automated
electrophoresis system is an effective method to determine the quality and
quantity of RNA in gene expression analysis experiments. The Experion system
accurately quantitates and evaluates the integrity of
samples using as little as 25 ng total RNA, which is
several hundred times less material than that required for gel electrophoresis.
Once RNA quantity and quality have been established, a researcher can determine
whether or not to move forward with additional experiments, knowing to what
degree the results may be compromised.
The six-page paper provides a
detailed introduction, methods description, results, and a discussion,
supported by numerous graphs, tables, figures, and electropherograms.
Availability
Bulletin
5452A is available either from a local Bio-Rad sales office or it may be
downloaded at www.bio-rad.com.
About Bio-Rad
Bio-Rad Laboratories, Inc. (AMEX: BIO and
BIOb) has remained at the center of scientific discovery for more than 50
years, manufacturing and distributing a broad range of products for the life
science research and clinical diagnostic markets. The company is renowned
worldwide among hospitals, universities, major research institutions, as well
as biotechnology and pharmaceutical companies for its commitment to quality and
customer service. Founded in 1952, Bio-Rad is headquartered in Hercules,
California, and serves more than 85,000 research and industry customers
worldwide through its global network of operations. The company employs over
6,300 people globally and had revenues of nearly $1.3 billion in 2006. For more
information, visit www.bio-rad.com.
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on Form 10-Q and Current Reports on Form 8-K. The Company cautions you not to
place undue reliance on forward-looking statements, which reflect an analysis
only and speak only as of the date hereof.
Bio-Rad Laboratories, Inc. disclaims any obligation to update these
forward-looking statements.
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more information, please contact:
Mary
Grace Brubacher
Bio-Rad
Laboratories, Inc.
510-741-5347
MaryGrace_Brubacher@bio-rad.com
Doug Forsyth
Alchymia Communications(r) LLC
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